Table 1.
Baseline patient characteristics
| Longitudinal | Cross-sectional | |||
|---|---|---|---|---|
| Characteristic | NA | HAD | HAD untreated | HAD treated |
| (n = 82) | (n = 10) | (n = 47) | (n = 20) | |
| Gender: male, number (%) | 49 (60) | 9 (90) | 44 (94) | 18 (90) |
| Age (years) | 38 (31–46) | 41 (35–46) | 40 (34–45) | 45 (38–52) |
| CD4+ T-cell count (× 106 cells/L) | 210 (70–330) | 68 (60–137) | 90 (17–175) | 49 (38–52) |
| CD4+ nadir T-cell count (× 106 cells/L) | 180 (60–250) | 52 (16–80) | 141 (18–160)c | 65 (50–130)e |
| Plasma HIV RNA (log10 copies/mL) | 4.79 (4.32–5.42) | 5.49 (5.32–5.78) | 4.87 (1.72–5.50) | < 1.70 |
| CSF HIV RNA (log10 copies/mL) | 3.78 (3.23–4.38) | 5.23 (5.09–5.41) | 4.16 (2.78–4.98) | < 1.70 |
| Albumin ratio | 4.26 (3.57–6.00) | 10.6 (7.50–17.24) | 9.90 (5.72–13.23) | 6.57 (4.87–7.36) |
| CSF neopterin (nmol/L) | 18.1 (11.5–24.0) | 50.4 (43.1–85.8)a | 50.0 (27.2–95.5) | 13.5 (9.6–17.9) |
| CSF NfL (ng/L) | 422 (318–713) | 14,115 (9824–23,543)b | 9731 (7603–21,555)d | f |
| Follow-up, days | 758 (230–1752) | 241 (50–994) | N/A | N/A |
If not stated otherwise, values are presented as median (IQR). IQR interquartile range, CSF cerebrospinal fluid, NA neuroasymptomatic, HAD: HIV-associated dementia. Missing values: a2/10, b4/10, c40/47 d43/47, e15/20, fno values. CSF NfL as age-adjusted values