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. 2021 Dec 7;11:724104. doi: 10.3389/fonc.2021.724104

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Copyright © 2021 Martincuks, Song, Kohut, Zhang, Li, Zhao, Mak, Rodriguez-Rodriguez, Yu and Cristea

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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STAT3 activity in ovarian cancer patient tumor-associated immune cells and fibroblasts is elevated post PARPi treatment. Representative immunofluorescence images of tumor sections from six gBRCA ovarian cancer patients before and after PARPi treatment showing p-STAT3 (green), pan-Cytokeratin (cyan), and either CD19+ B cells (red) in (A), CD4+ T cells (yellow) in (B), CD8+ T cells (magenta) in (C) or αSMA+ cancer-associated fibroblasts (red) in (D). Cytokeratin-stained cell clusters represent malignant tissue. Scale bars = 10 μm. Histograms (right) showing p-STAT3 expressing cell percentage within indicated populations. Unpaired two-tailed Student t-test performed against the before treatment group. Results represent means ± SD, n = 9 (nine images acquired before and nine images acquired after PARPi treatment from the same patient, six patients total). **p<0.01, ***p<0.001.