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. Author manuscript; available in PMC: 2021 Dec 22.
Published in final edited form as: Bioorg Med Chem. 2021 Nov 12;52:116504. doi: 10.1016/j.bmc.2021.116504

Figure 1.

Figure 1.

A. Process of hit-triage using MW (<350) and LipE (>2) leading to 8 chemotypes. B. Chemical structure of screening hit (1) with piperazine ureas scaffold with ring labeling and optimized lead 57.