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. Author manuscript; available in PMC: 2021 Dec 22.
Published in final edited form as: Bioorg Med Chem. 2021 Nov 12;52:116504. doi: 10.1016/j.bmc.2021.116504

Scheme 6.

Scheme 6.

Synthesis of analogs 51, 53, 55, 57 and 59. Reaction Conditions: (a) HATU (1.1 eq), DIPEA (5 eq), CH2Cl2, rt, overnight; (b) TFA-CH2Cl2 (1:1), rt, 1 h; (c) 6-chloronicotinonitrile (1.1 eq), Et3N (2 eq), acetonitrile, MW, 160 °C, 30 min.