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. Author manuscript; available in PMC: 2021 Dec 22.
Published in final edited form as: Bioorg Med Chem. 2021 Nov 12;52:116504. doi: 10.1016/j.bmc.2021.116504

Scheme 2.

Scheme 2.

Synthesis of analogs 28, 30, 31, 33 and 34. Reaction Conditions: (a) 6-(piperazin-1-yl)nicotinonitrile (64) (1 eq), acid (1.1 eq), HATU (1.1 eq), DIPEA (5 eq), CH2Cl2, rt, overnight.