TABLE 3.

Simple effects and effect sizes of significant cognitive domains (i.e., verbal learning and cued-recall) between baseline (X₁) and third follow-up (X₄) measures.

	Cluster	Δ X1–X4	Confidence interval for difference (95%)	P	Cohen’s d difference
Verbal learning	Irritability	3.66	2.48–4.84	<0.001	0.69
	Apathy	2.54	1.59–3.48	<0.001	0.49
	Anxiety/Depression	1.72	1.24–2.19	<0.001	0.31
	Asymptomatic	1.35	0.76–1.92	<0.001	0.22
Cued recall	Irritability	1.80	1.08–2.53	<0.001	0.64
	Apathy	1.88	1.30–2.47	<0.001	0.46
	Anxiety/Depression	0.70	0.40–0.99	<0.001	0.21
	Asymptomatic	1.05	0.69–1.41	<0.001	0.30

Cluster reflects neuropsychiatric symptoms class: Class 1 = Irritability; Class 2 = Apathy; Class 3 = Anxiety/Depression; Class 4 = Asymptomatic.

Confidence interval refers to mean differences.

Asymptomatic class was considered the reference category.

Age, MMSE, educational level, sex, conversion to dementia (yes/no), MCI type (amnestic/non-amnestic), and MCI profile (possible/probable) were also included in the models and were considered as fixed factors.

Δ X₁–X₄ = Difference of last follow-up from the baseline.