Figure 1.

HSC and progenitor cell loss during infection depends on both type I and II IFNs

Mice were infected with 10⁵ copies of IOE and bone marrow (BM) was analyzed day 7 post-IOE infection (dpi).

(A) Total BM cellularity is shown for WT, Ifngr^−/−, Ifnar^−/−, and Ifnar^−/−;Ifngr^−/− mice.

(B) The absolute numbers of total hematopoietic progenitors (HSPCs; Lin⁻ cKit⁺) is shown.

(C and D) (C) Long-term (LT)-HSCs and (D) short-term (ST)-HSCs of mice that were mock or IOE infected, n = 4–9 mice/group. ^∗p < 0.05, ^∗∗p < 0.001, ^∗∗∗p < 0.0001, ^∗∗∗∗p < 0.00001 (see Figure S1).