Figure 3. Vaccine Efficacy of NVX-CoV2373 in Specific Subgroups (Per-Protocol Efficacy Analysis Population).

Vaccine efficacy was defined as 1 minus the relative risk (NVX-CoV2373 minus placebo). Non-White race included end-point cases in participants from all other races to ensure that these subgroups would be large enough for meaningful analyses. The assessment of coexisting conditions is based on the Centers for Disease Control and Prevention definitions¹⁸ of persons at risk for complications of Covid-19. Participants at overall high risk for Covid-19 included those 65 years of age or older and those of any age with chronic health conditions or an increased risk for Covid-19 because of work or living conditions.