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Schematic representation showing Nrf2 translocation to the nucleus after dissociation from its inhibitory protein Keap1. In the nucleus, Nrf2 binds and activates ARE in the DNA, regulating the expression of several genes, including those involved in oxidative stress responses. ARE, antioxidant response element; Keap1, Kelch-like ECH associated protein-1; Nrf2, nuclear factor erythroid-2-related factor 2; Ub, Ubiquitin.
