Table 2.
Cohorta | WPa | BPa,c | ||||
---|---|---|---|---|---|---|
n | % | n | % | n | % | |
Patients eligible for analysis | 162 | 100 | 47 | 29 | 115 | 71 |
Age median (range) | 60 | 30–86 | 61 | 36–83 | 58 | 30–86 |
Age <60 | 88 | 50.8 | 21 | 46b | 67 | 58b |
HLA-A2 positive | 92 | 57 | 47 | 100 | 45 | 40 |
Surgical staging | ||||||
I a, b, c | 38 | 23 | 0 | 0 | 38 (22) | 33 |
II a, b, c | 17 | 10 | 0 | 0 | 15 (9) | 13 |
III a, b, c | 82 | 51 | 32 | 68 | 52 (9) | 45 |
IV | 25 | 15 | 15 | 32 | 10 (5) | 9 |
Stage merged | ||||||
A | 53 | 33 | 0 | 0 | 53 (31) | 46 |
B | 109 | 67 | 47 | 100 | 62 (14) | 54 |
Histopathology | ||||||
Serous | 87 | 52 | 47 | 100 | 40 (6d) | 35 |
Endometrioid | 45 | 28 | 0 | 0 | 45 (24) | 39 |
Mucinous | 14 | 9 | 0 | 0 | 14 (7) | 12 |
Clear cells | 10 | 6 | 0 | 0 | 10 (7) | 9 |
Others (mixed epithelial, undifferentiated) | 6 | 5 | 0 | 0 | 6 (1) | 5 |
Grade | ||||||
1 | 21 | 13 | 1 | 2 | 20 (11) | 17 |
2 | 34 | 21 | 10 | 21 | 24 (12) | 21 |
3 | 103 | 63 | 35 | 75 | 68 (21) | 59 |
Unknown | 4 | 3 | 1 | 2 | 3 (1) | 3 |
Treatments | ||||||
Primary surgery | 138 | 85 | 35 | 76 | 103 | 89 |
Radical surgery | 55 | 34 | 4 | 9 | 51 | 44 |
Secondary surgery | 22 | 14 | 8 | 17 | 14 | 12 |
Platinum-based chemotherapy | 152 | 94 | 45 | 97 | 107 | 92 |
Number of chemotherapy cycles | ||||||
6 and less | 97 | 60 | 15 | 33 | 82 | 71 |
More than 6 | 65 | 40 | 31 | 67 | 34 | 29 |
Radiotherapy | 7 | 4 | 3 | 7 | 4 | 3 |
aCohort: all patients included in the study. WP worst prognosis group, BP better prognosis group
bDifference in % between WP and BP is NS
cHLA-A02* genotype in parantheses
dHLA-A02* genotype patients: 4 in stage I and 2 in stage II