Table 2.
Characteristics of the cohort and groups
| Cohorta | WPa | BPa,c | ||||
|---|---|---|---|---|---|---|
| n | % | n | % | n | % | |
| Patients eligible for analysis | 162 | 100 | 47 | 29 | 115 | 71 |
| Age median (range) | 60 | 30–86 | 61 | 36–83 | 58 | 30–86 |
| Age <60 | 88 | 50.8 | 21 | 46b | 67 | 58b |
| HLA-A2 positive | 92 | 57 | 47 | 100 | 45 | 40 |
| Surgical staging | ||||||
| I a, b, c | 38 | 23 | 0 | 0 | 38 (22) | 33 |
| II a, b, c | 17 | 10 | 0 | 0 | 15 (9) | 13 |
| III a, b, c | 82 | 51 | 32 | 68 | 52 (9) | 45 |
| IV | 25 | 15 | 15 | 32 | 10 (5) | 9 |
| Stage merged | ||||||
| A | 53 | 33 | 0 | 0 | 53 (31) | 46 |
| B | 109 | 67 | 47 | 100 | 62 (14) | 54 |
| Histopathology | ||||||
| Serous | 87 | 52 | 47 | 100 | 40 (6d) | 35 |
| Endometrioid | 45 | 28 | 0 | 0 | 45 (24) | 39 |
| Mucinous | 14 | 9 | 0 | 0 | 14 (7) | 12 |
| Clear cells | 10 | 6 | 0 | 0 | 10 (7) | 9 |
| Others (mixed epithelial, undifferentiated) | 6 | 5 | 0 | 0 | 6 (1) | 5 |
| Grade | ||||||
| 1 | 21 | 13 | 1 | 2 | 20 (11) | 17 |
| 2 | 34 | 21 | 10 | 21 | 24 (12) | 21 |
| 3 | 103 | 63 | 35 | 75 | 68 (21) | 59 |
| Unknown | 4 | 3 | 1 | 2 | 3 (1) | 3 |
| Treatments | ||||||
| Primary surgery | 138 | 85 | 35 | 76 | 103 | 89 |
| Radical surgery | 55 | 34 | 4 | 9 | 51 | 44 |
| Secondary surgery | 22 | 14 | 8 | 17 | 14 | 12 |
| Platinum-based chemotherapy | 152 | 94 | 45 | 97 | 107 | 92 |
| Number of chemotherapy cycles | ||||||
| 6 and less | 97 | 60 | 15 | 33 | 82 | 71 |
| More than 6 | 65 | 40 | 31 | 67 | 34 | 29 |
| Radiotherapy | 7 | 4 | 3 | 7 | 4 | 3 |
aCohort: all patients included in the study. WP worst prognosis group, BP better prognosis group
bDifference in % between WP and BP is NS
cHLA-A02* genotype in parantheses
dHLA-A02* genotype patients: 4 in stage I and 2 in stage II