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. Author manuscript; available in PMC: 2022 Jul 1.

Published in final edited form as: Clin Pharmacol Ther. 2021 Mar 11;110(1):82–97. doi: 10.1002/cpt.2166

This comparison was generated with the comparative allele viewer (CAVE) tool and depicts all star alleles with c.516G>T (Q172H) and/or c.785A>G (K262R) except CYP2B6*29, a CYP2B7-2B6 hybrid that harbors 23 amino acid changes including Q152H. Blue boxes indicate the presence of a core SNV on all suballeles, while the gray box indicates that the core SNV is not present on all suballeles. The function () symbol indicates that a core SNV alters function and the PharmVar () symbol highlights that a core SNV is unique to a star allele. Of note, since c.785A>G is increasing function of CYP2B6*4 it is thus annotated with the function symbol and consistently shown as such across alleles. The impact of this SNV on the function of an allele with an additional SNV(s) may be minor or unclear. SNV positions refer to transcript coordinates on the NM_000767.5 reference sequence.

Inline graphic — This comparison was generated with the comparative allele viewer (CAVE) tool and depicts all star alleles with c.516G>T (Q172H) and/or c.785A>G (K262R) except CYP2B6*29, a CYP2B7-2B6 hybrid that harbors 23 amino acid changes including Q152H. Blue boxes indicate the presence of a core SNV on all suballeles, while the gray box indicates that the core SNV is not present on all suballeles. The function () symbol indicates that a core SNV alters function and the PharmVar () symbol highlights that a core SNV is unique to a star allele. Of note, since c.785A>G is increasing function of CYP2B6*4 it is thus annotated with the function symbol and consistently shown as such across alleles. The impact of this SNV on the function of an allele with an additional SNV(s) may be minor or unclear. SNV positions refer to transcript coordinates on the NM_000767.5 reference sequence.