. Author manuscript; available in PMC: 2021 Dec 22.

Published in final edited form as: Mol Nutr Food Res. 2020 Jul 6;64(15):e2000341. doi: 10.1002/mnfr.202000341

Table 2.

XN, DXN and TXN induce expression of FXR target genes in HepG2 cell lines, their effect is stronger than FXR agonist CDCA. Data are shown as Log₂ Fold Change Treated/Control ± SEM of n = 3 per group. Vehicle-treated cells were used as reference.

	CDCA	XN	DXN	TXN
Shp	0.93^** ± 0.27	1.21^** ± 0.27	1.92^**** ± 0.27	1.474^*** ± 0.27
Cyp7a1	−0.26 ± 0.29	4.29^**** ± 0.29	2.34^**** ± 0.29	1.13^** ± 0.29
Bsep	−0.02 ± 0.25	1.21^** ± 0.25	2.41^**** ± 0.25	0.60^* ± 0.25
Srebp1c	−0.50 ± 0.24	−0.31 ± 0.24	0.39 ± 0.24	0.64^* ± 0.24

p < 0.05

^**

p < 0.01

^***

p < 0.001

^****

p < 0.0001.