TABLE 2.
Results of carbapenemase detection using four assaysa
| ATCC strain | KPC variant | Nucleotide | Amino-acid substitution | Other β-lactams genes | MIC (mg/L) |
Detection method |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ETP | IPM | MEM | CZA | MEV | mCIM | eCIM | APB/EDTA | NG-test Carba 5 | GeneXpert Carba-R | |||||
| BAA-1705 | KPC-2 | − | − | − | >32 (R) | 16 (R) | 32 (R) | 0.5 (S) | ≤0.06 (S) | + | − | Class A carbapenemase + | KPC+ | KPC+ |
| BAA-2146 | NDM-1 | − | − | − | >32 (R) | >32 (R) | >32 (R) | >64 (R) | >64 (R) | + | + | MBL+ | NDM+ | NDM+ |
| 25922 | − | − | − | − | ≤0.06 (S) | 0.125 (S) | ≤0.06 (S) | 0.5 (S) | ≤0.06 (S) | − | − | − | − | − |
a
ETP, ertapenem; IPM, imipenem; MEM, meropenem; CZA, ceftazidime-avibactam; MEV, meropenem-vaborbactam.