TABLE 1.

Derived binding energy of aspirin and other molecules to BKRB2 and projected effects on BK binding to BKRB2

Drug	Binding energy to BkRB2 (kcal/mol)	Binding energy of BK to BKRB2 in presence of drug (kcal/mol)
		−6.6
Aspirin	−6.4	−5.5
Naloxone	−8.7	−5.9
Alogliptin	−8.6	−6.3
Colchicine	−7.8	−5.5
Arthemether	−8.2	−6.0
Galantamine	−7.9	−6.0
Apomorphine	−9.0	−5.7
Demeclocycline	−9.4	−6.3
Aztreonam	−7.4	−5.8
Podophyllin	−8.5	−5.8
Morphine	−8.4	−6.3