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. 2021 Nov 1;32(21):ar28. doi: 10.1091/mbc.E21-01-0010

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FIGURE 6: — The ARHGAP4-SEPT2/9 complex regulates FAs by mediating Integrin Beta 1 expression in HEK293 cells. (A) Immunoblots show that SEPT2 and SEPT9 depletion up-regulate ARHGAP4 expression; meanwhile, ARHGAP4 depletion does not affect SEPT2 and SEPT9. (B) Quantification of A with the mean and SD. (C) Immunoblots show that FAK and paxillin expression is increased with SEPT2 overexpression, and is reversed by ARHGAP4 overexpression. (D) Immunoblots show that FAK and paxillin expression is increased with SEPT9 overexpression, and is reversed by ARHGAP4 overexpression. (E) Immunoblots show that the expression of Integrin Beta 1 is decreased by SEPT2 depletion but reversed by ARHGAP4 depletion, is increased by ARHGAP4 depletion, and is decreased by SEPT9 depletion but reversed by ARHGAP4 depletion. (F) Quantification of E. Data are shown by the mean and SD.