Table 4.
Ki Values of Alkaloids 1–10 at the Human μ-Opioid Receptor
| alkaloid |
μ-opioid, Ki ± SEM (nM) |
average abundance in malaysian samples (% w/w) (except T3 and T4) |
|---|---|---|
| corynoxine (1) | 16.4 ± 1.4 | 0.18 |
| corynoxine B (2) | 109.8 ± 8.1 | 0.06 |
| Isospeciofoline (3) | 789.4 ± 293.8 | 0.03 |
| mitragynine oxindole B (4) | 1715.9 ± 12.0 | 0.13 |
| corynantheidine (5)6 | 1910 ± 50.0 | 0.22 |
| mitragynine (6)6 | 161 ± 10.0 | 14.11 |
| speciogynine (7)28 | 728 ± 61.0 | 1.48 |
| paynantheine (8)28 | 410 ± 15.2 | 1.39 |
| speciociliatine (9)6 | 54.5 ± 4.4 | 3.4 |
| speciociliatine N(4)-oxide (10) | 552.7 ± 22.5 | 0.01 |
| DAMGO | 0.403 ± 0.008 | |
| morphine | 4.19 (2.03–11.1)a |
a
95% confidence limit.