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. Author manuscript; available in PMC: 2022 Apr 23.
Published in final edited form as: J Nat Prod. 2021 Feb 26;84(4):1034–1043. doi: 10.1021/acs.jnatprod.0c01055

Table 5.

Statistical Analyses of Dose–Effect Functions for the Antinociceptive Effects of Test Compounds (i.v.) as Shown in Figure 5a

drug sex dose (mg/kg, i.v.) interaction post hoc test
morphine + 0.1 mg/kg naltrexone F1,16 = 0.0129; p = 0.915 F4,16 = 14.3; p < 0.001 F4,16 = 0.205; p = 0.932 17.8 mg/kg vs vehicle (t = 6.05, p < 0.001), 17.8 mg/kg vs naltrexone (t = 5.72, p < 0.001)
corynoxine (1) + 0.1 mg/kg naltrexone F1,20 = 1.73; p = 0.259 F5,20 = 54.3; p < 0.001 F5,20 = 0.882; p = 0.478 17.8 mg/kg vs vehicle (t = 10.2, p < 0.001), 17.8 mg/kg vs naltrexone (t = 10.2, p < 0.001)
a

The sample sizes are described in each figure legend. Comparisons were made using a two-way repeated-measures ANOVA followed by post hoc Bonferroni t tests with results shown when effects were statistically significant. Significant differences are in bold.