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Schematic representation of TEAD and ZO-2 movement in and out of the nucleus, regulated by the NLS and NES of ZO-2 and by the activity of PKA and nPKC δ and ε. In epithelial MDCK cells, nPKCδ blocks ZO-2 and TEAD interaction, inhibiting nuclear importation and exportation of the ZO-2/TEAD complex. PKA blocks ZO-2 nuclear importation, while nPKCε activates a NES of ZO-2 and the exportation of TEAD either alone or associated to ZO-2.
