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Activity of lead compounds against VSV pseudotype MERS viral entry into human Calu-3 lung epithelial cells
| Name/structure | MERS VSV pseudotype Calu-3 EC50 (nM) | Mouse plasma stability t1/2 (min) | Human plasma stability t1/2 (min) |
| Camostat | 5.0 | ND | ND |
| 2 (VD2173) | 273 | 222 | >289 |
| 7 (MM3116) | 2.3 | 154 | >289 |
| 6 (MM3144) | 0.55 | >289 | >289 |
| 5 (MM3123) | 2.9 | >289 | >289 |
| 4 (MM3122) | 0.87 | >289 | >289 |
Also shown is the plasma stability of selected compounds in both mouse and human plasma.
