Inhibitory assessment of the tested compounds 1 and 3c in comparison with sorafenib against EGFR, VEGFR-2 and BRAF^V600Ea.

Compound no.	IC50 (mean ± SEM) (μM)
	EGFR	VEGFR-2	BRAFV600E
Sorafenib	0.025 ± 0.10	1.022 ± 0.15	0.040 ± 0.13
1	0.022 ± 1.00	2.470 ± 0.30	2.026 ± 0.50
3c	0.017 ± 0.05	2.259 ± 0.45	0.088 ± 0.01

^aIC₅₀: compound concentration required to inhibit the enzyme activity by 50%, SEM: standard error mean; each value is the mean of three values.