Table 1.
Baseline Characteristics for All Patients (n = 35)
| Characteristic | Value |
|---|---|
| Age (years), median (range) | |
| Initial diagnosis | 4.8 (0.8–16.3) |
| RT1 start | 5.0 (1.2–16.4) |
| RT2 start | 7.2 (2.4–22.3) |
| Female sex (%) | 12 (34.3) |
| Initial site of ependymoma (%) | |
| Infratentorial | 27 (77.1) |
| Supratentorial | 8 (22.9) |
| Initial histologic grade (%) | |
| II | 12 (34.3) |
| III | 23 (65.7) |
| Molecular classification (%) | |
| PF-A | 15 (42.9) |
| PF-B | 1 (2.9) |
| RELA fused | 3 (8.6) |
| Equivocal/unknown | 16 (45.6) |
| Copy number alterations, infratentorial (%) | |
| 1q intact | 8 (100) |
| 6q intact | 8 (100) |
| Unknown | 19 |
| Pre-RT1 extent of resection (%) | |
| GTR | 16 (45.7) |
| NTR | 10 (28.57) |
| STR | 9 (25.71) |
| RT1 dose (Gy), median (range) | 55.8 (52.2-59.4) |
| RT1 modality (%) | |
| Photon—focal | 31 (88.6) |
| Proton—focal | 4 (11.4) |
| Pre-RT2 extent of resection (%) | |
| GTR | 23 (65.7) |
| NTR | 5 (14.3) |
| STR | 5 (14.3) |
| No surgery | 2 (5.7) |
| RT2 modality (%) | |
| Photon—focal | 21 (60.0) |
| Photon—CSI + focal boost | 7 (20.0) |
| Proton—focal | 5 (14.3) |
| Photon—SRS | 2 (5.7) |
| RT2 CSI dose (Gy), median (range) | 23.4 (23.4-36.0) |
| RT2 dose (Gy), median (range) | 54 (15-59.4)a |
aTwo patients received stereotactic radiosurgery of 15 Gy and 24 Gy.