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. 2021 Dec 8;9:772436. doi: 10.3389/fcell.2021.772436

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Copyright © 2021 Xu, Zhu, Tian, Liu, Wu, Anwaier, Su, Wei, Qu, Zhang and Ye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The overall depiction of genetic variations of m⁵C regulators in ccRCC. (A) The dynamic reversible process of m⁵C DNA methylation mediated by regulators as well as their potential biological functions for ccRCC are summarized. (B) Comparison of the expression levels of 17 m⁵C regulators in 530 ccRCC samples and >12,000 para-cancer tissues. (C) Copy number variations (CNVs) of the 17 m⁵C regulators in ccRCC from TCGA cohort. (D) Somatic variant landscape of the 17 m⁵C regulators in ccRCC from TCGA cohort. (E) The location of CNV alterations of m⁵C regulators on chromosomes. (F) Principal component analysis of ccRCC samples from the TCGA cohort based on the expression of the 17 m⁵C regulators.