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. 2021 Dec 8;9:772436. doi: 10.3389/fcell.2021.772436

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Copyright © 2021 Xu, Zhu, Tian, Liu, Wu, Anwaier, Su, Wei, Qu, Zhang and Ye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TME characterization in the m⁵C modification phenotypes. TME characterization assessment between high and low m⁵C score groups based on IHC staining (CD4, CD8, FoxP3, PD-L1, GLUT-1, CXCL13, TGF-β, FASN, Ki-67) and opal multimarkers IHC staining (DAPI, CK, CD4, CD8, FoxP3, PD-L1).