In vitro antimicrobial activity of the sulphonamide and carbamate derivatives of Nebivolol intermediate (8a–g & 9a–d).
| Compound | MIC in μg mL−1 | |||
|---|---|---|---|---|
| Bacillus subtillis | Staphylococcus aureus | Escherichia coli | Pseudomonas aeruginosa | |
| Streptomycin | 25.40 ± 0.48 | 18.64 ± 1.07 | 26.40 ± 1.12 | 28.18 ± 0.80 |
| 8a | 31.60 ± 1.03 | 21.88 ± 0.33 | 30.14 ± 0.72 | 31.88 ± 1.04 |
| 8b | 15.08 ± 0.08 | 17.88 ± 0.61 | 12.68 ± 0.87 | 22.42 ± 0.40 |
| 8c | 21.60 ± 0.44 | 19.66 ± 0.62 | 17.12 ± 0.47 | 22.18 ± 0.63 |
| 8d | 18.30 ± 0.21 | 17.44 ± 0.40 | 24.17 ± 0.72 | 27.40 ± 0.65 |
| 8e | 19.66 ± 0.36 | 20.42 ± 0.62 | 26.26 ± 0.28 | 26.72 ± 0.88 |
| 8f | 16.22 ± 0.94 | 19.88 ± 0.66 | 24.06 ± 1.02 | 26.84 ± 0.55 |
| 8g | 14.32 ± 0.27 | 10.22 ± 0.52 | 12.06 ± 0.36 | 18.46 ± 0.12 |
| 9a | 20.49 ± 0.76 | 16.56 ± 0.35 | 21.70 ± 1.06 | 19.48 ± 1.25 |
| 9b | 25.98 ± 0.42 | 20.32 ± 0.06 | 21.14 ± 0.45 | 30.36 ± 0.22 |
| 9c | 26.08 ± 0.30 | 19.04 ± 1.08 | 22.72 ± 0.26 | 28.81 ± 0.60 |
| 9d | 27.66 ± 0.44 | 18.08 ± 0.80 | 27.22 ± 0.92 | 31.66 ± 0.88 |