In vitro antifungal activity of the sulphonamide and carbamate derivatives of Nebivolol intermediate (8a–g & 9a–d).
Compound | MIC in μg mL−1 | ||
---|---|---|---|
Aspergillus niger | Aspergillus flavus | Rhizopus arrhizus | |
Fluconazole | 19.40 ± 0.17 | 18.38 ± 0.32 | 22.32 ± 0.45 |
8a | 22.32 ± 0.27 | 23.06 ± 0.25 | 22.80 ± 0.54 |
8b | 20.40 ± 0.87 | 17.81 ± 0.16 | 20.21 ± 0.65 |
8c | 18.10 ± 0.46 | 16.72 ± 0.70 | 22.22 ± 0.83 |
8d | 15.30 ± 0.15 | 17.04 ± 0.70 | 18.65 ± 0.65 |
8e | 11.71 ± 0.35 | 14.08 ± 0.55 | 16.64 ± 0.52 |
8f | 15.66 ± 0.69 | 16.18 ± 0.82 | 19.04 ± 0.20 |
8g | 14.06 ± 0.72 | 15.18 ± 0.80 | 14.36 ± 0.66 |
9a | 11.20 ± 1.08 | 12.66 ± 0.80 | 14.18 ± 0.69 |
9b | 24.72 ± 0.70 | 23.81 ± 0.67 | 19.24 ± 0.48 |
9c | 19.32 ± 0.47 | 19.81 ± 0.37 | 25.56 ± 0.48 |
9d | 28.46 ± 0.14 | 25.20 ± 0.66 | 31.28 ± 0.45 |