In vitro COX-1 and COX-2 enzyme inhibitory activities of title compounds (8a–g & 9a–d).

Compound	% inhibition of COXa
	COX-1		COX-2
	100 μM	200 μM	100 μM	200 μM
8a	37.30 ± 0.32	45.52 ± 0.77	23.53 ± 0.55	38.64 ± 0.33
8b	46.10 ± 0.22	68.78 ± 0.43	34.43 ± 0.66	60.04 ± 0.24
8c	51.08 ± 0.62	70.07 ± 0.70	40.40 ± 0.10	61.20 ± 0.72
8d	53.88 ± 0.30	69.64 ± 0.18	39.32 ± 0.77	63.88 ± 0.46
8e	48.42 ± 0.84	71.55 ± 0.15	35.55 ± 0.22	57.72 ± 0.36
8f	33.87 ± 1.06	73.85 ± 0.54	28.70 ± 0.07	52.08 ± 0.78
8g	47.69 ± 0.63	71.08 ± 0.16	39.92 ± 0.51	67.60 ± 0.73
9a	50.66 ± 0.33	75.33 ± 0.14	18.06 ± 0.88	52.42 ± 0.21
9b	43.08 ± 0.80	69.02 ± 0.50	37.70 ± 0.35	63.60 ± 0.32
9c	39.60 ± 0.08	51.64 ± 0.32	24.30 ± 0.20	41.66 ± 0.23
9d	41.40 ± 0.62	52.16 ± 0.30	29.73 ± 0.75	38.59 ± 0.29
Celecoxib	46.52 ± 0.40	68.07 ± 0.50	31.60 ± 0.44	51.32 ± 0.17

^aThe determination was performed in triplicate for two independent experiments.