Anti-inflammatory activity of the title compounds against the carrageenan-induced paw edema in rats with different time intervals^a.

Compound	Dose (mg kg−1 p.o.)	Paw volume (mL)
		1 h	3 h	6 h
Control	—	0.42 ± 0.40	0.38 ± 0.14	0.40 ± 0.60
Carrageenan	—	0.94 ± 0.15##	1.17 ± 0.22##	1.69 ± 0.84#
8b	100	0.52 ± 0.18*	0.80 ± 0.38**	1.06 ± 0.27*
8c	100	0.60 ± 0.64**	0.88 ± 0.31**	1.11 ± 0.13**
8d	100	0.78 ± 0.88*	1.08 ± 0.40*	1.50 ± 0.64*
8e	100	0.68 ± 0.96*	0.74 ± 0.29*	1.19 ± 0.65*
8f	100	0.62 ± 0.10**	0.86 ± 0.32*	1.10 ± 0.13*
8g	100	0.65 ± 0.20*	0.77 ± 0.28**	1.20 ± 0.38**
9a	100	0.72 ± 0.72*	1.06 ± 0.52*	1.56 ± 0.33*
9b	100	0.76 ± 0.48*	0.88 ± 0.16**	1.50 ± 0.25*
Celecoxib	100	0.80 ± 0.50**	0.98 ± 0.92*	1.58 ± 0.22**

^a*Each value is the mean ± SEM for six rats. ^#p < 0.05, ^##p < 0.01 when compared with normal control group. **p < 0.01, *p < 0.05 when compared with carrageenan control group.