Screening reaction conditionsa.
| |||||
|---|---|---|---|---|---|
| Entry | Solvent | Catalyst (mol%) | Temp. (°C) | TBHP (mmol) | Yieldb (%) |
| 1 | Water | 1 | 40 | 2 | 40 |
| 2 | EtOH | 1 | 40 | 2 | 85 |
| 3 | CH3CN | 1 | 40 | 2 | 60 |
| 4 | Solvent free | 1 | 40 | 2 | 97 |
| 5 | Solvent free | — | 40 | 2 | 25 |
| 6 | Solvent free | 0.5 | 40 | 2 | 65 |
| 7 | Solvent free | 1.5 | 40 | 2 | 97 |
| 8 | Solvent free | 2 | 40 | 2 | 90 |
| 9 | Solvent free | 1 | r.t, | 2 | 50 |
| 10 | Solvent free | 1 | 50 | 2 | 97 |
| 11 | Solvent free | 1 | 60 | 2 | 75 |
| 12 | Solvent free | 1 | 70 | 2 | 65 |
| 13 | Solvent free | 1 | 40 | 1 | 75 |
| 14 | Solvent free | 1 | 40 | 3 | 85 |
a
Reaction conditions: benzyl alcohol (1 mmol), 20 min.
b
Yields of product isolated.