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. 2021 Dec 18;14:6993–7006. doi: 10.2147/JIR.S340351

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© 2021 Chen et al.

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Results from quantitative proteomic analysis verified from PRM were displayed. (A) 5 proteins including fibrinogen beta chain, testicular tissue protein Li 70, C reactive protein, serotransferrin, haptoglobin from the 13 overlapping DEPs detected via iTRAQ were confirmed by PRM and compared between responders and non-responders. The results of PRM confirmed significant differences in the expression changes of TF. (B) bioinformatics analysis showed upstream pathway of TF was associated with HIF-1 signal. (C) bioinformatics analysis showed downstream pathway of TF was associated with ferroptosis.

Abbreviations: DEPs, differentially expressed proteins; HIF-1, hypoxia inducible factor-1; iTRAQ, isobaric tags for relative and absolute quantification; PRM, parallel reaction monitoring; TF, serotransferrin.