Table 1.
Differentially Expressed Proteins in Responders Compared Between 0 Week and 14 Weeks’ Treatment
| UniProtKB ID | Protein Name | Protein Description | Fold Change a | p-value | Reference |
|---|---|---|---|---|---|
| Up-regulation | |||||
| F6KPG5 | ALB | Albumin (Fragment) | 2.191646 | 1.09E-06 | |
| P02768 | ALB | Serum albumin | 2.186348 | 1.17E-06 | *[21] |
| B2R5G8 | SAA | Serum amyloid A protein | 1.688033 | 0.00112 | |
| K7ELP7 | KRT17 | Keratin, type I cytoskeletal 17 (Fragment) | 1.620485 | 0.00265 | |
| P02787 | TF | Serotransferrin | 1.577649 | 0.004514 | *[32] |
| A0A0A0MS14 | IGHV1-45 | Protein IGHV1-45 (Fragment) | 1.561166 | 0.005523 | |
| A8K4W8 | N/A | cDNA FLJ77917, highly similar to Homo sapiens ubiquitin-conjugating enzyme E2L3 (UBE2L3), transcript variant 1, mRNA | 1.543972 | 0.006805 | * |
| Q53FL1 | N/A | Tumor endothelial marker 8 isoform 3 variant (Fragment) | 1.521399 | 0.008922 | |
| P30043 | BLVRB | Flavin reductase (NADPH) | 1.516692 | 0.009435 | * |
| Q0ZCI2 | IG | Immunglobulin heavy chain variable region (Fragment) | 1.469428 | 0.016403 | |
| F6IR49 | HLA-A | MHC class I antigen (Fragment) | 1.463367 | 0.017585 | |
| Q86YQ4 | HBA1 | Alpha-1 globin (Fragment) | 1.459135 | 0.018458 | |
| P35443 | THBS4 | Thrombospondin-4 | 1.448261 | 0.020889 | |
| G3XAP6 | COMP | Cartilage oligomeric matrix protein | 1.443717 | 0.021991 | |
| O95408 | HBB | Beta globin (Fragment) | 1.441775 | 0.022478 | |
| A0A075B6L1 | IGLC7 | Ig lambda-7 chain C region (Fragment) OS=Homo sapiens | 1.418328 | 0.029207 | |
| A0A068LN03 | IG | Ig heavy chain variable region (Fragment) | 1.415796 | 0.030036 | |
| A0A0F7SZ86 | IGHV2-70 | IGHV2-70 protein (Fragment) | 1.413793 | 0.030707 | |
| B2R701 | N/A | cDNA, FLJ93202, Homo sapiens protease inhibitor 16 (PI16), mRNA | 1.408237 | 0.032642 | |
| P06396 | GSN | Gelsolin | 1.408101 | 0.032691 | [16] |
| Q12860 | CNTN1 | Contactin-1 | 1.404455 | 0.034022 | |
| V9H1C1 | N/A | Gelsolin exon 4 (Fragment) | 1.396393 | 0.037145 | |
| A0A109PW33 | MS-C1 | MS-C1 light chain variable region (Fragment) | 1.39345 | 0.038349 | |
| B7Z6K2 | N/A | Polypeptide N-acetylgalactosaminyltransferase | 1.380871 | 0.04391 | |
| B4DEW5 | N/A | cDNA FLJ54049, highly similar to Multimerin-2 | 1.379853 | 0.04439 | * |
| P03950 | ANG | Angiogenin | 1.375668 | 0.046417 | |
| Down-regulation | |||||
| P02741 | CRP | C-reactive protein | 0.236029 | 6.76E-12 | * |
| P0DJI9 | SAA2 | Serum amyloid A-2 protein | 0.327456 | 1.14E-07 | |
| P0DJI8 | SAA1 | Serum amyloid A-1 protein | 0.375431 | 3.28E-06 | |
| P05109 | S100A8 | Protein S100-A8 | 0.405983 | 1.87E-05 | |
| D3DQX7 | SAA1 | Serum amyloid A protein | 0.447267 | 0.000134 | |
| B2R4M6 | S100 | Protein S100b | 0.452564 | 0.000168 | |
| H0YCJ8 | RHCE | Blood group Rh (CE) polypeptide (Fragment) | 0.466308 | 0.000294 | |
| P59665 | DEFA1 | Neutrophil defensin 1 | 0.526796 | 0.002371 | *[28] |
| Q96KK5 | HIST1H2AH | Histone H2A type 1-H OS=Homo sapiens | 0.547712 | 0.004318 | |
| B2RDW0 | N/A | cDNA, FLJ96792, highly similar to Homo sapiens 1 2 (phosphorylase kinase, delta) (CALM2), mRNA | 0.55186 | 0.004832 | |
| P00738 | HP | Haptoglobin OS=Homo sapiens | 0.557742 | 0.005648 | *,[23,24] |
| A0A140VJJ6 | N/A | Testicular tissue protein Li 70 | 0.562781 | 0.006436 | *[12] |
| Q15465 | SHH | Sonic hedgehog protein OS=Homo sapiens | 0.568021 | 0.00735 | |
| A0A087WZB5 | PARVB | Beta-parvin OS=Homo sapiens | 0.572798 | 0.008274 | |
| P05164 | MPO | Myeloperoxidase | 0.574748 | 0.008678 | * |
| G3V1A4 | CFL1 | Cofilin 1 (Non-muscle) | 0.578453 | 0.009489 | *[25,26] |
| Q9UPN3 | MACF1 | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 | 0.580073 | 0.009863 | |
| P02675 | FGB | Fibrinogen beta chain | 0.585197 | 0.011126 | *[12] |
| P02763 | ORM1 | Alpha-1-acid glycoprotein 1 | 0.593449 | 0.013435 | |
| P63267 | ACTG2 | Actin, gamma-enteric smooth muscle | 0.614606 | 0.021155 | |
| K7EMV3 | H3F3B | Histone H3 | 0.62008 | 0.023637 | |
| X6RJP6 | TAGLN2 | Transgelin-2 (Fragment) | 0.627781 | 0.027511 | |
| P23381 | WARS | Tryptophan–tRNA ligase, cytoplasmic | 0.630046 | 0.028739 | |
| P31146 | CORO1A | Coronin-1A | 0.631905 | 0.029779 | |
| Q05315 | CLC | Galectin-10 | 0.632977 | 0.030392 | * |
| Q02985 | CFHR3 | teinComplement factor H-related pro3 | 0.640014 | 0.034661 | |
| P00558 | PGK1 | Phosphoglycerate kinase 1 | 0.646196 | 0.038779 | |
| A8K9J7 | N/A | Histone H2B | 0.649774 | 0.041328 | |
| B2MUD5 | ELA2 | Neutrophil elastase (Fragment) | 0.652207 | 0.043133 | [28] |
| P07737 | PFN1 | Profilin-1 | 0.657025 | 0.046881 |
Notes: aFold change (14 week /0 weeks.). *13 overlapping DEPs between Rs and NRs group.