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. 2021 Dec 18;14:6993–7006. doi: 10.2147/JIR.S340351

Table 2.

Differentially Expressed Proteins in Non-Responders Compared Between 0 Week and 14 Weeks’ Treatment

UniProtKB ID Protein Name Protein Description Fold Change a p-value Reference
Up-regulation
Q5T619 ZNF648 Zinc finger protein 648 2.725262 1.46E-13
Q6VFQ6 HBB Hemoglobin beta chain (Fragment) 2.587354 2.41E-12
D3GKD8 HBG1 A-gamma globin Osilo variant 2.56063 4.16E-12
A0A0K0K1L1 HEL-S-282 Epididymis secretory protein Li 282 2.467484 2.76E-11 [12]
Q4TZM4 HBB Hemoglobin beta chain (Fragment) 2.253802 2.07E-09
Q05315 CLC Galectin-10 2.226055 3.61E-09 *
P02042 HBD Hemoglobin subunit delta 2.135777 2.19E-08
P00915 CA1 Carbonic anhydrase 1 2.1189 3.06E-08
I1VZV6 HBA1 Hemoglobin alpha 1 2.103325 4.16E-08
B4DF70 N/A cDNA FLJ60461, highly similar to Peroxiredoxin-2 (EC 1.11.1.15) 1.954513 7.67E-07
U3PXP0 HBA2 Alpha globin chain (Fragment) 1.872493 3.69E-06
C9JH23 BPGM Phosphoglycerate mutase (Fragment) 1.869616 3.90E-06
Q14CN4 KRT72 Keratin, type II cytoskeletal 72 1.850513 5.59E-06
B2M1S7 N/A Beta-globin Showa Yakushiji variant (Fragment) 1.81085 1.18E-05
B3VL17 N/A Beta globin (Fragment) 1.782137 2.01E-05
U6A3P2 HBA2 Mutant hemoglobin alpha 2 globin chain (Fragment) 1.660955 0.00018
F8WCJ1 EIF5A2 Eukaryotic translation initiation factor 5A 1.641945 0.000251
P30041 PRDX6 Peroxiredoxin-6 1.57379 0.000811
Q8IUL9 HBB Hemoglobin beta chain variant Hb. Sinai-Bel Air (Fragment) 1.565149 0.000938
H0YID2 AK1 Adenylate kinase isoenzyme 1 (Fragment) 1.539678 0.001434
P30043 BLVRB Flavin reductase (NADPH) 1.529225 0.001704 *
P02533 KRT14 Keratin, type I cytoskeletal 14 1.504589 0.002544
H6VRF8 KRT1 Keratin 1 1.501174 0.002688
Q6MZQ6 DKFZp686G11190 Putative uncharacterized protein DKFZp686G11190 1.480119 0.003764
P04746 AMY2A Pancreatic alpha-amylase 1.454008 0.005669
P13645 KRT10 Keratin, type I cytoskeletal 10 1.439906 0.007048
F5H265 UBC Polyubiquitin-C (Fragment) 1.422328 0.009209
A0A140VJJ6 N/A Testicular tissue protein Li 70 1.419386 0.009627 *[12]
P04040 CAT Catalase 1.409613 0.011146
P50395 GDI2 Rab GDP dissociation inhibitor beta 1.400381 0.012784
P35527 KRT9 Keratin, type I cytoskeletal 9 1.387761 0.015389
A0A068LL60 N/A Ig heavy chain variable region (Fragment) 1.378007 0.017732
Q6MZX9 DKFZp686M08189 Putative uncharacterized protein DKFZp686M08189 1.377605 0.017835
P02675 FGB Fibrinogen beta chain 1.347919 0.027197 *[12]
A8K4W8 N/A cDNA FLJ77917, highly similar to Homo sapiens ubiquitin-conjugating enzyme E2L 3 (UBE2L3), transcript variant 1, mRNA 1.334983 0.032541 *
E5RIF1 UBE2V Ubiquitin-conjugating enzyme E2 variant 2 (Fragment) 1.328734 0.035451
B4DEW5 N/A cDNA FLJ54049, highly similar to Multimerin-2 1.321043 0.039356 *
G3V1A4 CFL1 Cofilin 1 1.310441 0.045378 *
P10599 TXN Thioredoxin 1.309389 0.046019
P35908 KRT2 Keratin, type II cytoskeletal 2 epidermal 1.307819 0.04699
A0A0A0MSI0 PRDX1 Peroxiredoxin-1 (Fragment) 1.307281 0.047327
Down-regulation
P07996 THBS1 Thrombospondin-1 0.614035 0.0002 [16]
P08254 MMP3 Stromelysin-1 0.632381 0.000477
P05164 MPO Myeloperoxidase 0.650635 0.001054 *[25,26]
G3V2V8 NPC2 Epididymal secretory protein E1 (Fragment) 0.685575 0.004032
B7Z7M2 N/A cDNA FLJ51564, highly similar to Pregnancy zone protein 0.703391 0.007375
P59665 DEFA1 Neutrophil defensin 1 0.703815 0.007477 *[28]
P02741 CRP C-reactive protein 0.71003 0.009119 *
Q5NV83 V3-3 V3-3 protein 0.718231 0.011745
Q5NV74 V2-14 V2-14 protein 0.722984 0.013539
B7Z7R8 N/A cDNA FLJ55622, highly similar to Multimerin-1 0.723099 0.013585
P02768 ALB Serum albumin 0.723382 0.013699 *[21]
P00738 HP Haptoglobin 0.723422 0.013715 *[23,24]
P01854 IGHE Ig epsilon chain C region 0.723721 0.013836
A0N7I9 F5-20 F5-20 (Fragment) 0.727805 0.015587
G5E968 CHGA Chromogranin A (Parathyroid secretory protein 1), isoform CRA_b 0.728291 0.015807
Q5FWF9 IGL@ IGL@ protein 0.75488 0.032428
A0A024R9Q1 THBS1 Thrombospondin 1, isoform CRA_a 0.756766 0.034006 [16]
P02776 PF4 Platelet factor 4 0.761463 0.038202 [21]
P02787 TF Serotransferrin 0.76795 0.044665 *[32]
C9IZL7 NONO Non-POU domain-containing octamer-binding protein (Fragment) 0.769253 0.046061
Q569I7 N/A Uncharacterized protein 0.771193 0.048204

Notes: aFold change (14 week /0 weeks). *13 overlapping DEPs between Rs and NRs group.