Table 2.
Differentially Expressed Proteins in Non-Responders Compared Between 0 Week and 14 Weeks’ Treatment
UniProtKB ID | Protein Name | Protein Description | Fold Change a | p-value | Reference |
---|---|---|---|---|---|
Up-regulation | |||||
Q5T619 | ZNF648 | Zinc finger protein 648 | 2.725262 | 1.46E-13 | |
Q6VFQ6 | HBB | Hemoglobin beta chain (Fragment) | 2.587354 | 2.41E-12 | |
D3GKD8 | HBG1 | A-gamma globin Osilo variant | 2.56063 | 4.16E-12 | |
A0A0K0K1L1 | HEL-S-282 | Epididymis secretory protein Li 282 | 2.467484 | 2.76E-11 | [12] |
Q4TZM4 | HBB | Hemoglobin beta chain (Fragment) | 2.253802 | 2.07E-09 | |
Q05315 | CLC | Galectin-10 | 2.226055 | 3.61E-09 | * |
P02042 | HBD | Hemoglobin subunit delta | 2.135777 | 2.19E-08 | |
P00915 | CA1 | Carbonic anhydrase 1 | 2.1189 | 3.06E-08 | |
I1VZV6 | HBA1 | Hemoglobin alpha 1 | 2.103325 | 4.16E-08 | |
B4DF70 | N/A | cDNA FLJ60461, highly similar to Peroxiredoxin-2 (EC 1.11.1.15) | 1.954513 | 7.67E-07 | |
U3PXP0 | HBA2 | Alpha globin chain (Fragment) | 1.872493 | 3.69E-06 | |
C9JH23 | BPGM | Phosphoglycerate mutase (Fragment) | 1.869616 | 3.90E-06 | |
Q14CN4 | KRT72 | Keratin, type II cytoskeletal 72 | 1.850513 | 5.59E-06 | |
B2M1S7 | N/A | Beta-globin Showa Yakushiji variant (Fragment) | 1.81085 | 1.18E-05 | |
B3VL17 | N/A | Beta globin (Fragment) | 1.782137 | 2.01E-05 | |
U6A3P2 | HBA2 | Mutant hemoglobin alpha 2 globin chain (Fragment) | 1.660955 | 0.00018 | |
F8WCJ1 | EIF5A2 | Eukaryotic translation initiation factor 5A | 1.641945 | 0.000251 | |
P30041 | PRDX6 | Peroxiredoxin-6 | 1.57379 | 0.000811 | |
Q8IUL9 | HBB | Hemoglobin beta chain variant Hb. Sinai-Bel Air (Fragment) | 1.565149 | 0.000938 | |
H0YID2 | AK1 | Adenylate kinase isoenzyme 1 (Fragment) | 1.539678 | 0.001434 | |
P30043 | BLVRB | Flavin reductase (NADPH) | 1.529225 | 0.001704 | * |
P02533 | KRT14 | Keratin, type I cytoskeletal 14 | 1.504589 | 0.002544 | |
H6VRF8 | KRT1 | Keratin 1 | 1.501174 | 0.002688 | |
Q6MZQ6 | DKFZp686G11190 | Putative uncharacterized protein DKFZp686G11190 | 1.480119 | 0.003764 | |
P04746 | AMY2A | Pancreatic alpha-amylase | 1.454008 | 0.005669 | |
P13645 | KRT10 | Keratin, type I cytoskeletal 10 | 1.439906 | 0.007048 | |
F5H265 | UBC | Polyubiquitin-C (Fragment) | 1.422328 | 0.009209 | |
A0A140VJJ6 | N/A | Testicular tissue protein Li 70 | 1.419386 | 0.009627 | *[12] |
P04040 | CAT | Catalase | 1.409613 | 0.011146 | |
P50395 | GDI2 | Rab GDP dissociation inhibitor beta | 1.400381 | 0.012784 | |
P35527 | KRT9 | Keratin, type I cytoskeletal 9 | 1.387761 | 0.015389 | |
A0A068LL60 | N/A | Ig heavy chain variable region (Fragment) | 1.378007 | 0.017732 | |
Q6MZX9 | DKFZp686M08189 | Putative uncharacterized protein DKFZp686M08189 | 1.377605 | 0.017835 | |
P02675 | FGB | Fibrinogen beta chain | 1.347919 | 0.027197 | *[12] |
A8K4W8 | N/A | cDNA FLJ77917, highly similar to Homo sapiens ubiquitin-conjugating enzyme E2L 3 (UBE2L3), transcript variant 1, mRNA | 1.334983 | 0.032541 | * |
E5RIF1 | UBE2V | Ubiquitin-conjugating enzyme E2 variant 2 (Fragment) | 1.328734 | 0.035451 | |
B4DEW5 | N/A | cDNA FLJ54049, highly similar to Multimerin-2 | 1.321043 | 0.039356 | * |
G3V1A4 | CFL1 | Cofilin 1 | 1.310441 | 0.045378 | * |
P10599 | TXN | Thioredoxin | 1.309389 | 0.046019 | |
P35908 | KRT2 | Keratin, type II cytoskeletal 2 epidermal | 1.307819 | 0.04699 | |
A0A0A0MSI0 | PRDX1 | Peroxiredoxin-1 (Fragment) | 1.307281 | 0.047327 | |
Down-regulation | |||||
P07996 | THBS1 | Thrombospondin-1 | 0.614035 | 0.0002 | [16] |
P08254 | MMP3 | Stromelysin-1 | 0.632381 | 0.000477 | |
P05164 | MPO | Myeloperoxidase | 0.650635 | 0.001054 | *[25,26] |
G3V2V8 | NPC2 | Epididymal secretory protein E1 (Fragment) | 0.685575 | 0.004032 | |
B7Z7M2 | N/A | cDNA FLJ51564, highly similar to Pregnancy zone protein | 0.703391 | 0.007375 | |
P59665 | DEFA1 | Neutrophil defensin 1 | 0.703815 | 0.007477 | *[28] |
P02741 | CRP | C-reactive protein | 0.71003 | 0.009119 | * |
Q5NV83 | V3-3 | V3-3 protein | 0.718231 | 0.011745 | |
Q5NV74 | V2-14 | V2-14 protein | 0.722984 | 0.013539 | |
B7Z7R8 | N/A | cDNA FLJ55622, highly similar to Multimerin-1 | 0.723099 | 0.013585 | |
P02768 | ALB | Serum albumin | 0.723382 | 0.013699 | *[21] |
P00738 | HP | Haptoglobin | 0.723422 | 0.013715 | *[23,24] |
P01854 | IGHE | Ig epsilon chain C region | 0.723721 | 0.013836 | |
A0N7I9 | F5-20 | F5-20 (Fragment) | 0.727805 | 0.015587 | |
G5E968 | CHGA | Chromogranin A (Parathyroid secretory protein 1), isoform CRA_b | 0.728291 | 0.015807 | |
Q5FWF9 | IGL@ | IGL@ protein | 0.75488 | 0.032428 | |
A0A024R9Q1 | THBS1 | Thrombospondin 1, isoform CRA_a | 0.756766 | 0.034006 | [16] |
P02776 | PF4 | Platelet factor 4 | 0.761463 | 0.038202 | [21] |
P02787 | TF | Serotransferrin | 0.76795 | 0.044665 | *[32] |
C9IZL7 | NONO | Non-POU domain-containing octamer-binding protein (Fragment) | 0.769253 | 0.046061 | |
Q569I7 | N/A | Uncharacterized protein | 0.771193 | 0.048204 |
Notes: aFold change (14 week /0 weeks). *13 overlapping DEPs between Rs and NRs group.