Skip to main content
. 2021 Jan 25;11(8):4740–4750. doi: 10.1039/d0ra08836f

Pharmacokinetic parameters of the developed method.

Parameter Unit Metformin (300 mg kg−1) Metformin + fenugreek extract, 300 + 500 (mg kg−1)
T 1/2 h 2.95 1.94
T max h 1.00 2.00
C max μg mL−1 15.14 26.90
AUC0–t μg mL−1 h−1 42.82 106.43
AUC0–inf μg mL−1 h−1 52.60 119.32
Mean residence time (MRT) h 4.01 3.54
Volume of distribution (Vd/F) L 24.25 7.05
Clearance (Cl/F) L h−1 5.70 2.51