Pharmacokinetic parameters of the developed method.
| Parameter | Unit | Metformin (300 mg kg−1) | Metformin + fenugreek extract, 300 + 500 (mg kg−1) |
|---|---|---|---|
| T 1/2 | h | 2.95 | 1.94 |
| T max | h | 1.00 | 2.00 |
| C max | μg mL−1 | 15.14 | 26.90 |
| AUC0–t | μg mL−1 h−1 | 42.82 | 106.43 |
| AUC0–inf | μg mL−1 h−1 | 52.60 | 119.32 |
| Mean residence time (MRT) | h | 4.01 | 3.54 |
| Volume of distribution (Vd/F) | L | 24.25 | 7.05 |
| Clearance (Cl/F) | L h−1 | 5.70 | 2.51 |