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Co-occurring MET amplification and secondary mutations. (A) VAF of METex14 concurrent with MET amplification versus METex14 only in Guardant360. (B) Second site MET mutations in patients with METex14 non–small-cell lung cancer in Guardant360 and GenePlus data sets. IPT, immunoglobulin plexins transcription domains; METex14, MET exon 14 skipping alterations; PSI, plexins-semaphorin-integrin domain; TM, transmembrane domain; VAF, variant allele frequency.
