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. 2021 Jan 26;11(8):4829–4841. doi: 10.1039/d0ra10170b

Acute oral toxicity of saponin on the food intake, body weight and food utilization rate in ratsa.

Sex Saponin dose (g per kg per body weight) Food intake (g) Body weight (g) Food utilization rate (%)
Male 0 444.00 ± 6.07 138.00 ± 10.66 31.06 ± 1.84
1 420.00 ± 7.32** 106.00 ± 14.78* 25.35 ± 2.88*
2.15 410.00 ± 6.98** 95.00 ± 9.66** 23.14 ± 2.05**
4.64 428.00 ± 7.57** 108.00 ± 17.78* 25.28 ± 4.39*
10 375.00 ± 9.29** 97.00 ± 13.57** 25.68 ± 2.80*
Female 0 262.00 ± 4.56 67.00 ± 9.27 25.54 ± 3.09
1 247.00 ± 5.01* 51.00 ± 3.81* 20.63 ± 1.12*
2.15 233.00 ± 7.68** 44.00 ± 6.53** 18.84 ± 2.18**
4.64 242.00 ± 8.52* 46.00 ± 0.57** 19.02 ± 0.43**
10 226.00 ± 13.10** 44.00 ± 10.58** 19.33 ± 3.57*
a

All data are means ± standard deviation (n = 5 in each group, **Significant difference at P < 0.01 level when compared with the control group, *Significant difference at P < 0.05 level when compared with the control group).