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. 2021 Dec 8;12:740707. doi: 10.3389/fphar.2021.740707

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Copyright © 2021 Fusaroli, Raschi, Gatti, De Ponti and Poluzzi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Disproportionality Heat Map. showing significant disproportionalities (after the Bonferroni correction) between HLTs (clustered by SOC, on the right) and the main suspected drugs in COVID-19 patients. Associations are colour-coded (white when not calculated, grey when not significant, red when significant). SOCs: Vascular, Skin, Respiratory, Renal, Psychiatric, Pregnancy, Nervous, Muscular, Metabolic, Infective, Hepatic, Gastrointestinal, Eye, Ear, Cardiac, Blood. Drugs: remdesivir, lopinavir, hydroxychloroquine, azithromycin, tocilizumab, sarilumab, ethanol.