Skip to main content
. 2021 Dec 22;7(52):eabk3273. doi: 10.1126/sciadv.abk3273

Fig. 3. Active site and nucleotide interactions.

Fig. 3.

(A) Orientation of the lever arm in BH and FH in comparison to the pre-powerstroke state (PDB ID: 1QVI). (B) Active site and nucleotide interactions in the FH. Key residues are shown in stick representation. The distance between R247 and E470 is >6.1 Å. (C) Active site and nucleotide interactions in the BH. Key residues are shown in stick representation. (D) Comparison between the active sites in BH and FH. Key residues are shown in stick representation. (E) Comparison between the active sites in BH, FH, and the pre-powerstroke state (PDB ID: 2XEL). The salt bridge between switch-1 R247/R238 and switch-2 E470/E459 is only formed in the pre-powerstroke state and absent in BH and FH. Key residues are shown in stick representation. (F) Comparison of the phosphate release tube in the BH and FH.