IC₅₀ values of different drug groups against MCF-7 cells (n = 6)^a.

Cell lines	IC50 (μg mL−1)
	FEVO	FBBR	FEVO/BBR = 6 : 1	LEVO	LBBR	LEVO/BBR = 6 : 1, NO	LEVO/BBR = 6 : 1
MCF-7	50.39 ± 1.52	42.03 ± 0.96	31.98 ± 0.88	19.40 ± 0.75	14.81 ± 1.16	16.01 ± 1.27	10.18 ± 0.72

^aAbbreviation: IC₅₀, half-maximal inhibitory concentration; FEVO, free evodiamine; FBBR, free berberine; FEVO/BBR, mechanically mixed free evodiamine and berberine; LEVO, SiO₂–Na₂CO₃@EVO-LB; LBBR, SiO₂–BBR–Na₂CO₃@LB; LEVO/BBR, SiO₂–BBR–Na₂CO₃@EVO-LB; NO, no Na₂CO₃.