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. Author manuscript; available in PMC: 2021 Dec 22.
Published in final edited form as: Oncogene. 2021 Mar 8;40(14):2553–2566. doi: 10.1038/s41388-020-01599-z

Fig. 8. A proposed model to illustrate the regulatory mechanism of RGS12 on Ezrin expression in osteosarcoma.

Fig. 8.

In normal bone, RGS12 promotes the growth arrest of osteosarcoma through inhibiting YAP nuclear translocation. In osteosarcoma bone, RGS12 has a lower expression and knockdown of RGS12 enhances RhoA activity and the transcriptional activity of YAP/TEAD1 to induce Ezrin expression.