Sub-threshold dose sleep latency and sleep duration tests of pentobarbital sodium in mice and rats in the different groupsa.
| Groups | Samples | Mice | Rats | ||||
|---|---|---|---|---|---|---|---|
| Dose (mg kg−1) | Sleep latency (min) | Sleep duration (min) | Dose (mg kg−1) | Sleep latency (min) | Sleep duration (min) | ||
| Control | 10 | 11.90 ± 3.11 | 38.20 ± 15.67 | 8.50 ± 2.10 | 20.00 ± 5.30 | ||
| LS | 10 | 400 | 5.88 ± 1.72*** | 81.90 ± 19.70*** | 300 | 5.10 ± 0.44** | 64.40 ± 11.29*** |
| LaS | 10 | 400 | 6.20 ± 3.02* | 69.60 ± 11.90** | 300 | 5.56 ± 1.20* | 62.34 ± 12.20*** |
| LaO | 10 | 400 | 8.30 ± 3.52* | 40.30 ± 8.32 | 300 | 7.42 ± 1.60 | 38.65 ± 8.45 |
| LaI | 10 | 0.03 | 6.40 ± 3.10** | 58.75 ± 10.60** | 0.03 | 6.20 ± 0.70* | 50.20 ± 10.10** |
| Diazepam | 10 | 5 | 6.20 ± 1.40*** | 65.47 ± 12.10** | 3.5 | 5.25 ± 0.48** | 63.50 ± 10.50*** |
Compared with the control group, ***P < 0.001, **P < 0.01, *P < 0.05.