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. 2021 Feb 3;11(11):5896–5902. doi: 10.1039/d0ra09751a

Sub-threshold dose sleep latency and sleep duration tests of pentobarbital sodium in mice and rats in the different groupsa.

Groups Samples Mice Rats
Dose (mg kg−1) Sleep latency (min) Sleep duration (min) Dose (mg kg−1) Sleep latency (min) Sleep duration (min)
Control 10 11.90 ± 3.11 38.20 ± 15.67 8.50 ± 2.10 20.00 ± 5.30
LS 10 400 5.88 ± 1.72*** 81.90 ± 19.70*** 300 5.10 ± 0.44** 64.40 ± 11.29***
LaS 10 400 6.20 ± 3.02* 69.60 ± 11.90** 300 5.56 ± 1.20* 62.34 ± 12.20***
LaO 10 400 8.30 ± 3.52* 40.30 ± 8.32 300 7.42 ± 1.60 38.65 ± 8.45
LaI 10 0.03 6.40 ± 3.10** 58.75 ± 10.60** 0.03 6.20 ± 0.70* 50.20 ± 10.10**
Diazepam 10 5 6.20 ± 1.40*** 65.47 ± 12.10** 3.5 5.25 ± 0.48** 63.50 ± 10.50***
a

Compared with the control group, ***P < 0.001, **P < 0.01, *P < 0.05.