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. 2021 Feb 3;11(10):5832–5858. doi: 10.1039/d0ra10755g

Summary of the strategies employed to the building of the 4-O-2,3,4,5-tetrasubstituted THPs.

NP Group Strategy
1 Masamune's (1997)17 Intramolecular nucleophilic addition
1 Evans' (1999)15 Intramolecular heteroconjugate addition
1 Trost's (2008)29 (1) Ru-catalyzed alkene–alkyne coupling, (2) Pd-catalyzed allylic alkylation
2a Markó's (2009)42
2a Lee's (2010)44 Intramolecular Prins cyclisation
2a Sasaki's (2012)55 Catalytic asymmetric hetero Diels–Alder reaction
2a Fürstner's (2013)66 Intramolecular oxy-Michael reaction
2a/2b Sasaki's (2017)73 Catalytic asymmetric hetero Diels–Alder reaction
2a Kadari & Yerrabelly's (2018)77
3a Jennings' (2006)88 (1) Molander–Reformatsky intramolecular aldol addition, (2) alkylation, (3) reduction
3a Jennings' (2007)95
3a Ghosh's (2007)98 Jacobsen catalytic asymmetric hetero-Diels–Alder
3a Ghosh's (2008)98a
3a Ghosh's (2012)107 Jacobsen catalytic asymmetric hetero-Diels–Alder
3a Trost's (2014)113 Simultaneous Hoveyda–Grubbs 2nd generation catalyzed cross metathesis/intramolecular oxa-Michael addition
3a Trost's (2018)123 Intramolecular oxa-Michael addition
3a Hong's (2018)124 Intramolecular oxa-Michael addition
4a Raghavan's (2017)134
4a Krische's (2019)143 Intramolecular alkoxypalladation/carbonylation of alkenes
5a Paterson's (2013)150 Intramolecular Michael cyclisation
5a Carter's (2016)158 Silver catalysed cyclisation of propargyl benzoate
5a Lee's (2016)162 Ir-catalysed visible light induced radical cyclisation