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. 2021 Feb 3;11(11):6099–6106. doi: 10.1039/d0ra09827b

Reactions of triazolium precursor 1 with 1-phenylpiperazinea.

graphic file with name d0ra09827b-u3.jpg
Entry Time (h) Yieldb (%)
1 3 5
1 5.5 68 25 7
2 10 60 32 8
3 24 43 47 10
4 48 28 59 13
a

All reactions were carried out on a 0.084 mmol reaction scale of triazolium precursor 1 in 0.75 mL of CD3CN in a sealed NMR tube. 1-Phenylpiperazine (3 equiv.) was used as a nucleophile.

b

1H NMR yields.