Reactions of triazolium precursor 1 with 1-phenylpiperazinea.
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Entry | Time (h) | Yieldb (%) | ||
1 | 3 | 5 | ||
1 | 5.5 | 68 | 25 | 7 |
2 | 10 | 60 | 32 | 8 |
3 | 24 | 43 | 47 | 10 |
4 | 48 | 28 | 59 | 13 |
All reactions were carried out on a 0.084 mmol reaction scale of triazolium precursor 1 in 0.75 mL of CD3CN in a sealed NMR tube. 1-Phenylpiperazine (3 equiv.) was used as a nucleophile.
1H NMR yields.