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. 2021 Feb 3;11(11):6060–6098. doi: 10.1039/d0ra10657g

In vitro inhibitory effects of compounds (7–9) against human COXs (reproduced with permission from A. A. Bekhit et al., Eur. J. Med. Chem., 2003, 38, 27–36, © 2003 Elsevier)77.

Investigated compound COX-1, IC50a (μM) COX-2, IC50a (μM)
Indomethacin 0.21 2.60
7 95.0 0.36
8 > 100 12.0
9 > 100 0.29
a

Values are means of a minimum of four experiments.