. 2021 Feb 3;11(11):6060–6098. doi: 10.1039/d0ra10657g

In vitro COXs suppression, IC₅₀ and SI values of the selected derivatives (reproduced with permission from G. N. Tageldin, et al., Bioorg. Chem., 2018, 78, 358–371, © 2018 Elsevier)⁷⁸.

Tested compound	COX-1, IC₅₀ (μM)^a	COX-2, IC₅₀ (μM)	SI^b (COX-1/COX-2)
10	2.74	0.22	12.45
11	5.88	0.69	8.52
12	3.89	0.54	7.20
13	4.74	0.69	6.86
14	4.74	0.87	5.44
Celecoxib	5.46	0.78	7.23
Diclofenac sodium	6.74	1.10	6.12

Values are average of three readings obtained and the variation from the average is ±10% of the average value.

In vitro COX-2 selectivity indices (COX-1 IC₅₀/COX-2 IC₅₀).

In vitro COXs suppression, IC50 and SI values of the selected derivatives (reproduced with permission from G. N. Tageldin, et al., Bioorg. Chem., 2018, 78, 358–371, © 2018 Elsevier)78.