In vitro cytotoxicity of A. awamori-derived extracts from different fermentation media and epigenetic modifiers treatments.

Tested extract	IC50 (μg mL−1)
	WI38	HCT116	HePG-2	MCF7
MDA	25.89 ± 2.9	24.10 ± 2.3	28.76 ± 2.1	29.70 ± 2.9
NA	83.05 ± 4.1	57.37 ± 3.3	64.16 ± 3.3	73.61 ± 4.1
RG	19.26 ± 2.5	9.39 ± 0.8	7.84 ± 0.6	11.48 ± 1.0
TSA	94.26 ± 5.1	38.57 ± 2.6	30.49 ± 2.3	42.65 ± 3.2
Valp	88.15 ± 4.5	53.42 ± 3.1	41.27 ± 2.6	64.73 ± 3.9
Nic	28.52 ± 2.1	17.49 ± 1.5	13.78 ± 1.1	19.18 ± 1.5
Tric	86.38 ± 4.3	49.01 ± 2.9	51.35 ± 3.0	62.79 ± 3.7
Aza	77.50 ± 3.8	73.83 ± 3.7	65.84 ± 3.6	87.22 ± 4.6
Doxa	6.72 ± 0.5	5.23 ± 0.3	4.50 ± 0.2	4.17 ± 0.2

^aDoxorubicin.