Results of the synthesis of 4a–4gvia the irradiation of 2a–2g in HCl/acetal at 419 nm.
En. | Starting | Conv. (%) | Yield (%) based on conversion | Yield of 4 (%) | 3-Step yield (%) |
---|---|---|---|---|---|
1 | 2a: H | 93 | 96 | 89.28 | 81.37 |
2 | 2b: Me | 76 | 86 | 65.36 | 57.69 |
3 | 2c: Et | 75 | 86 | 64.50 | 55.68 |
4 | 2d: i-Pr | 72 | 73 | 52.56 | 45.45 |
5 | 2e: F | 67 | 91 | 60.97 | 52.09 |
6 | 2f: Cl | 66 | 91 | 60.06 | 53.56 |
7 | 2g: Br | 77 | 90 | 69.30 | 63.80 |