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Comparison between p53 IHC patterns and TP53 mutation types in 92 GI-NEN cases.
| IHC staining pattern | Mutation types | |||||
|---|---|---|---|---|---|---|
| LOF | Wild type | GOF | ||||
| Nonsense | Frameshift | Splicing | Missense | In-frame | ||
| Pattern A | 5 | 3 | 3 | 2 | 0 | 0 |
| Pattern B | 1 | 0 | 1 | 33 | 0 | 0 |
| Pattern C1 | 1 | 0 | 1 | 0 | 3 | 1 |
| Pattern C2 | 1 | 1 | 0 | 3 | 29 | 4 |
| Total | 8 | 4 | 5 | 38 | 32 | 5 |
