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. 2021 Dec 23;185(4):603–613.e15. doi: 10.1016/j.cell.2021.12.026

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Figure S1 — Human lymph node T_FH population frequency correlates with the GC B cell population frequency, related to Figure 1; Tables 1 and S1

(A) Gating strategy for the lymph node T_FH (CD3⁺CD4⁺CXCR5⁺PD1⁺Bcl-6⁺FoxP3^-) and GC B cell (CD19⁺IgD^lowBcl-6⁺CD38^int) populations. Spike⁺ GC B cells are gated on cells that stain positive for two individual SARS-CoV-2 spike-protein probes.

(B) The T_FH population measured as the frequency of total lymph node CD4⁺ T cells were compared with the total frequency of lymph node GC B cells using linear regression.

(C) Total T_FH population frequency compared with the total frequency of spike-specific GC B cells. n = 95 individual lymph node samples obtained from all 15 study subjects between and including study days 21 and 200.