Skip to main content
. 2021 Feb 23;11(14):8323–8345. doi: 10.1039/d0ra08030f

The applications of multivariate methods in the mixing process.

Models Blender type Application References
MLR KG-5 blender The model was used to correlate the critical formulation and CPPs with the response variables. A design space for the powder mixing process was built 42
MLR Continuous mixer The relationship between residence time and total particle length was explored 43
Polynomial V-blender The effects of CPPs on CQAs were quantified to identify their relationship, and the design space was established 44
Quadratic model Cone shape tank Based on the regression model, the optimal mixing conditions, including the impeller speed and eccentricity, were found 45
PLS Twin-screw blender In twin-screw blend feeding, the relationship between blend material properties and feeding capacity was developed 46
PLS Square cone mixer The relationship between raw material variability and mixing time was quantified. The CMAs affecting the mixing process were identified according to VIP 47
PLS and MLR Continuous mixer The effect of material properties on the mean residence time was studied. The relationship between bulk density and mean residence time at different flow rates was determined 48