The applications of multivariate models in monitoring or detecting CQAs for tablets.

Model	Tool	Application	References
MLR	NIR	Detection of tablet hardness	199 and 206
	NIR	Measurement of drug content	207
PCA	NIR	Measurement of drug content	208
PCR	NIR	Detection of tablet hardness	209–212
	NIR	Measurement of tablet weight variation	212
	NIR	Prediction of tablet porosity	209
PLS	NIR	Detection of tablet hardness	199, 206, 207, 213 and 214
	NIR	Prediction of tablet porosity	213
	NIR	Measurement of tensile strength	215–217
	Multispectral UV imaging	Measurement of tensile strength	218
	NIR	Measurement of moisture	216
	NIR	Prediction of dissolution behavior	199 and 219–227
	NIR-CI	Prediction of dissolution behavior	228
	Raman	Prediction of dissolution behavior	224
	NIR	Measurement of drug content	199, 201, 203, 214, 216 and 229–249
	NIR-CI	Measurement of drug content	250 and 251
	Raman	Measurement of drug content	235, 248, 252 and 253
	MIR	Measurement of drug content	241
	Multispectral UV imaging	Measurement of drug content	218
	NIR	Measurement of disintegration time	254
	NIR	Measurement of tablet weight	237
ANN	NIR	Prediction of dissolution behavior	224
	Raman	Prediction of dissolution behavior	224
	NIR	Measurement of drug content	214, 229 and 255
	NIR	Detection of tablet hardness	214