Fig. 4. (a) Dose-dependence of HT-29 cell viability after 48 h treatment by blank liposomes (cyan), non-encapsulated cordycepin (purple) and encapsulated cordycepin (green). For statistical analysis, One-way ANOVA with post hoc Dunnett's test was performed. *P < 0.001 and **P < 0.0001 were considered as statistically significant. (b) HT-29 cells under microscope after treatment by blank liposomes and cordycepin-encapsulated liposomes. (Top) The cells' morphology changed after cordycepin-encapsulated treatment. (Bottom) Apoptotic cell death was detected after cordycepin-encapsulated treatment. The dead cells are shown in green.